Why do cholestatic patients itch?
نویسندگان
چکیده
منابع مشابه
Nocturnal itch: why do we itch at night?
Pruritus is exacerbated at night in many systemic and dermatological diseases, resulting in reports of significantly diminished quality of life and sleep disturbances. At present, the underlying mechanisms responsible for night-time itching are not well understood. Nocturnal pruritus may be related to the circadian rhythm of itch mediators and possibly the disruption of such patterns. Diurnal c...
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Lysophosphatidic acid (LPA) mediates cholestatic pruritus. Recently the enzyme PNPLA3, expressed in liver and skin, was demonstrated to metabolise LPA. Here we assess the association of the PNPLA3 variant p.Ile148Met, known to be associated with (non-)alcoholic fatty liver disease (NAFLD) in genome-wide association studies, with cholestatic itch in 187 patients with primary biliary cirrhosis (P...
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Patients with acne often scratch their lesions. As scratching is also a part of the response to pruritic stimuli, this study aimed to determine whether itching accompanies acne. A total of 108 teenagers (mean age 15.8+/-1.8 years) with acne were included in the study. All participants completed a specially designed questionnaire on demographic and clinical data. Itching accompanying acne lesion...
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A review of the literature reveals uniform acceptance of the fact that a relatively large percentage of tuberculosis patients reactivate regardless of extent of disease,8’ 14, 19 type of treatment whether bedrest,’” collapse therapy,9 long1’ or short term chemotherapy or resection.’8 Further, it is accepted that the rate of relapse is usually in proportion to the extent of disease and the amoun...
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Opioids such as morphine numb pain but often concomitantly induce itch. Liu et al. (2011) now separate the sensation of itch from opioid-induced analgesia, showing that in a subset of spinal neurons, morphine directly induces itch by signaling through a heteromer of opioid- and itch-mediating G protein-coupled receptors.
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ژورنال
عنوان ژورنال: Gut
سال: 1996
ISSN: 0017-5749
DOI: 10.1136/gut.38.5.644